Background:

May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).

Applications:

ELISA, IHC

Name of antibody:

TXNIP

Immunogen:

Synthetic peptide of humanTXNIP

Full name:

thioredoxin interacting protein

Synonyms：

THIF; VDUP1; HHCPA78; EST01027

SwissProt:

Q9H3M7

ELISA Recommended dilution:

2000-10000

IHC positive control:

Human esophagus cancer

IHC Recommend dilution:

30-150