Background:

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus.

Applications:

ELISA, IHC

Name of antibody:

WDR11

Immunogen:

Synthetic peptide of human WDR11

Full name:

WD repeat domain 11

Synonyms:

DR11; HH14; BRWD2; WDR15

SwissProt:

Q9BZH6

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human ovarian cancer and human tonsil

IHC Recommend dilution:

25-100